Research Group

Multimodal Imaging  (Multimodale Bildgebung)

Heads:  Prof Dr. R. Graf,  Prof Dr. G. Mies,  PD Dr. H. Endepols

Focal cerebral ischemia – Peri-infarct zone and remote effects

Research in the MultiModal Imaging (MMI) group investigates experimental and clinical stroke (focal ischemia) in the acute, subacute and chronic phase. After occlusion of brain arteries, injury processes are identified and related to long-term structural and functional deterioration and also to recovery processes.

For this purpose, longitudinal investigations are employed:

• Characterisation of pathophysiological processes in subcritically disturbed ischemic border zones in the acute phase of focal ischemia
• Experimental and clinical investigations of the subacute phase of focal ischemia, with special consideration of hemispheric, malignant stroke
• Characterization of remote effects of the primary ischemic lesion in the chronic phase of ischemia, with the central question of how the rest brain outside the primary lesion meets structural and functional deficits derived from that primary lesion

Multimodal methods include:

• Dynamic imaging of regional cortical blood flow using µPET and „Laser Speckle“ 
• Invasive imaging with autoradiographic methods
• Invasive acquisition of intracranial pressure, tissue ptiO2, extracellular ion and substrate concentration using ion selective electrodes and microdialysis, spontaneous and evoked electrical activity
• µPET in combination with behavioral paradigms
  
  
  

Research topics in detail:

Acute Phase

Subacute Phase

Chronic Phase

Spreading depolarizations occur in human ischemic stroke with high incidence

Waves of spreading depolarization have often been observed in experimental stroke models...

more...

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