Research & Service Group
Cyclotron / Radiochemistry:
Production and development of PET-radiopharmaceuticals for preclinical und clinical research
Main tasks of the group Radiochemistry
The Research and Development Group Radiochemistry/Cyclotron is responsible for the production of radiopharmaceuticals and the development of radiotracers for the application in human and animal research studies.
Radiolabelled probes enable the visualization, quantification and tracking of metabolic processes using Positron Emission Tomography (PET) at a molecular level. The in vivo PET image of molecular probes is directly related to the interaction of the radiotracer with the target. Molecular interactions are for example metabolic turnovers with subsequent retention in the target structure or binding of the radioligands to specific receptors. Therefore, a rational selection of suitable molecular targets, tailor-made probe design and automated radiosynthesis of optimal imaging probes addressing these specific targets are prerequisites to understand biological processes underlying normal or diseased states at the molecular level.
The main tasks of our group are:
- Production of radiopharmaceuticals for preclinical and clinical research
- Development of radio-labelled probes for molecular imaging
- Application and development of novel radio-labelling techniques and methods
The MC16 cyclotron (Scanditronix, Uppsala, Sweden) enables the versatile acceleration of protons and deuterons to produce various PET-isotopes. The produced radionuclides are transported to the hot cells in capillary lines.