In-vivo-NMR Head: Prof. Dr. Mathias Hoehn
Regeneration of cerebral lesions
Our research interest focuses on regeneration of cerebral lesions, in particular stroke. We pursue the goal of regeneration through implantation of embryonic stem cells and thereby explore their therapeutic potential. The following aspects are in the center of our attention:
Methodologically, our investigations rely heavily on in vivo MRI data, complemented by optical imaging, and invasive histological and immunohistochemical staining techniques. Physiological and electrophysiological monitoring are an integral part of our protocols. An increasing number of studies includes molecular biological techniques: transgenic cells are generated with modified functions or cells are generated which produce their own reporters for in vivo imaging, both MRI and optical imaging.
Research topics in detail:
May 22, 2014
Markus Aswendt receives DFG grant for molecular imaging of neural stem cell fate
The German Science Foundation (DFG) approved a 3 year funding of a unique approach: the non-invasive targeting of neural stem cell fate by optical imaging. Specific fluorescence and bioluminescence imaging reporters will be used to discriminate undifferentiated from differentiated cells in vivo. Markus Aswendt is working as a postdoctoral fellow in the In-vivo-NMR group of Prof. Mathias Hoehn and gets the chance to pursue independent research building on experiments during his PhD. This project will combine with high-field magnetic resonance imaging expertise to provide structural and functional tracking of the in vivo stem cell fate – an essential step towards stem cell therapy.
"Spatio-temporal dynamics, differentiation and viability of
ESMI Poster Award 2011
With his poster on "Effect of anesthesia on functional connectivity networks of the rat brain" Daniel Kalthoff convinced the ESMI-Jury and got one of ten awards assigned to outstanding junior researchers. Nearly 200 posters were presented at the EMIM conference.